RxODE: Facilities for Simulating from ODE-Based Models

Facilities for running simulations from ordinary differential equation (ODE) models, such as pharmacometrics and other compartmental models. A compilation manager translates the ODE model into C, compiles it, and dynamically loads the object code into R for improved computational efficiency. An event table object facilitates the specification of complex dosing regimens (optional) and sampling schedules. NB: The use of this package requires both C and Fortran compilers, for details on their use with R please see Section 6.3, Appendix A, and Appendix D in the "R Administration and Installation" manual. Also the code is mostly released under GPL. The VODE and LSODA are in the public domain. The information is available in the inst/COPYRIGHTS.

Version: 0.9.1-0
Depends: R (≥ 3.4.0)
Imports: Matrix, PreciseSums (≥ 0.3), Rcpp (≥ 0.12.3), brew, cli, crayon, digest, dparser (≥ 0.1.8), ggforce, ggplot2, inline, magrittr, memoise, methods, mvnfast, n1qn1 (≥ 6.0.1-2), pillar, rex, sys, units (≥ 0.6-0), utils, assertthat, lotri, remotes
LinkingTo: dparser (≥ 0.1.8), Rcpp (≥ 0.12.3), RcppArmadillo (≥ 0.9.300.2.0), PreciseSums (≥ 0.3)
Suggests: knitr, DT, nlme, shiny, tcltk, testthat, usethis, devtools, covr, rmarkdown, SnakeCharmR, dplyr (≥ 0.8.0), tidyr, tibble, curl, gridExtra, microbenchmark, scales, stringi, htmltools, reticulate, rlang, installr
Published: 2019-07-12
Author: Matthew L. Fidler ORCID iD [aut], Melissa Hallow [aut], Wenping Wang [aut, cre], Zufar Mulyukov [ctb], Justin Wilkins ORCID iD [ctb], Simon Frost [ctb], Heng Li [ctb], Yu Feng [ctb], Alan Hindmarsh [ctb], Linda Petzold [ctb], Ernst Hairer [ctb], Gerhard Wanner [ctb], J Colinge [ctb], Hadley Wickham [ctb], G Grothendieck [ctb], Robert Gentleman [ctb], Ross Ihaka [ctb], R core team [cph], odepack authors [cph]
Maintainer: Wenping Wang <wwang8198 at gmail.com>
BugReports: https://github.com/nlmixrdevelopment/RxODE/issues
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
Copyright: see file COPYRIGHTS
URL: https://nlmixrdevelopment.github.io/RxODE/
NeedsCompilation: yes
Citation: RxODE citation info
CRAN checks: RxODE results


Reference manual: RxODE.pdf
Vignettes: Changing RxODE compartment numbers
RxODE Covariates
RxODE Data Frames
RxODE Events
Introduction to RxODE
RxODE additional model types
Compiled RxODE models in Packages
RxODE and Shiny
RxODE Jacobian specification and Stiff Systems
RxODE ODE solving syntax
RxODE Transit Compartment Models
Package source: RxODE_0.9.1-0.tar.gz
Windows binaries: r-devel: not available, r-release: not available, r-oldrel: RxODE_0.9.1-0.zip
OS X binaries: r-release: RxODE_0.9.1-0.tgz, r-oldrel: RxODE_0.9.1-0.tgz
Old sources: RxODE archive


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